custom-written matlab 2015b program  (MathWorks Inc)

Journal: Scientific Reports

Article Title: Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint

doi: 10.1038/srep45223

Figure Lengend Snippet: Trabecular bone parameters measured in this study were derived from tibial epiphysis of non-loaded and loaded knees. Bone volume fraction (BV/TV) ( A ), trabecular number ( B ), trabecular thickness ( C ), trabecular spacing ( D ) and trabecular CDI (E) did not differ significantly between 6N and 9N groups at days 5, 9, and 14 or between 9N and 12N groups at days 14, 28 and 56. Trabecular SMI ( F ) increased significantly at day 14 in 9N and 12N groups than 6N group but did not change with time. There were no significant differences for apparent BMD ( G ). Coronal images were used for measurement of subchondral bone plate thickness in the medial and lateral tibial plateau. Subchondral bone thickness measurement showed that there were no significant differences in thickness of subchondral bone plate between non-loaded and loaded knees. However, there was a significant increase in subchondral bone plate thickness in 12N group at day 56 compared to days 14 and 28 ( H ). BV = bone volume, TV = tissue volume, Tb.N = trabecular number, Tb.Th = trabecular thickness, Tb.Sp. = trabecular spacing, CDI = connectivity density index, SMI = structure model index, BMD = bone mineral density. *Compared to 6N 5 day, # compared to 6N 9 day, $ compared to 6N 14 day, ^ compared to 9N 5 day, + compared to 9N 56 day,/compared to 12N 14 day, x compared to 12N 28 day.

Article Snippet: Subchondral bone thickness was measured using a custom-written MATLAB-2015b (Mathworks) program .

Techniques: Derivative Assay